Spring 2019 BIOL5591 Topics

Lecture	Topic(s)	Links
Lecture 1, January 8	Natarajan writing assignment Dideoxy chain termination Illumina sequencing SOLiD sequencing	Sanger Sequencing Illumina Sequencing SOLiD Sequencing
Lecture 2, January 10	PacBio sequencing Pyrosequencing Fisher's exact test and Chi-squared test	Pyrosequencing PacBio SMRT Sequencing Fisher's Exact Test
Lecture 3, January 15	Association loci and rare variants Burden tests SKAT	Burden tests SKAT [Review of rare variants]
Lecture 4, January 17	SOLiD sequencing review	SOLiD Sequencing
Lecture 5, January 22	Drawing phylogenetic trees	Basic Phylogenetic Trees
Lecture 6, January 24	Evolution of color vision
Lecture 7, January 29	Building phylogenetic trees with UGene	Building phylogenetic trees with UGene
Lecture 8, January 31	Building phylogenetic trees with UGene HIV Evolution DropSeq	Building phylogenetic trees with UGene Phylogenetic trees by hand Single Cell RNA Sequencing
Lecture 9, February 5	tSNE qPCR and ddPCR	tSNE qPCR and ddPCR
Lecture 10, February 7	Review: rare and low-frequency variants Haplotype Phasing Genotype imputation Manhattan Plots De Bruijn Graphs Trinity	Phasing Imputation Manhattan Plots De Bruijn Graphs Trinity
Lecture 11, February 12	Quantile Normalization	Quantile Normalization
Lecture 12, February 14	QQ Plots	QQ Plots
Lecture 13, February 19	Bomba 2017 Paper	Bomba 2017 Reading
Lecture 14, February 21	Bomba 2017 Presentations	Bomba 2017 Reading
Lecture 15, February 26	Exam Review, Presentations	N/A
Lecture 16, February 28	Exam	N/A
EXAM Cutoff	=	=
Lecture 17, March 12
Lecture 18, March 14
Lecture 19, March 19
Lecture 20, March 21
Lecture 21, March 26
Lecture 22, March 28
Lecture 23, April 2
Lecture 24, April 4
Lecture 25, April 9
Lecture 26, April 11
Lecture 27, April 16